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KMID : 0615720010180050135
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Jouranl of Korean Acupuncture and Moxibustion society
2001 Volume.18 No. 5 p.135 ~ p.146
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Healing of Bony Defects by Cervi Pantotricuhum Cornu Herbal Acupuncture
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Abstract
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Objective : Bone homeostasis is maintained by balance of bone formation and resorption. Therefore, bone related diseases arose by disturbance of this balance between osteoblast and osteoclast activities. To develop a successful screening system of the therapeutic components based on oriental medicine is essential to set out systematic approach for that purpose.
Methods : This study was perforated Sprague-Dawley rat femur for bony defects(φ 5㎜) by the fissure bur. And experimetal group were treated with Cervi Pantotricuhum Cornu injection at both She｀nshu～(BL23) & Da｀zhu｀(BL11)(0.2㎖). This was evaluated by radiography and histological analysis with in situ hybridization.
Results : Cervi Pantotricuhum Cornu Herbal Acupuncture has weak effect on bony defect healing and this was evaluated by X-ray taking and histological analysis with in situ hybridization. Osteocalcin gene expression was not changed by Cervi Pantotricuhum Cornu Herbal Acupuncture in bony defects animal model.
Conclusion : Taken together this study show that the Cervi Pantotricuhum Cornu herbal-acupuncture has a weak effect healing of bony defects, this type of approach might give a good chance to explore the favorable effects of Cervi Pantotricuhum Cornu herbal-acupuncture on bone tissue.
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